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Your Profile Luigi Martino
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| Luigi Martino | |
| Luigi | |
| Martino | |
| scholar.google.co.uk/citations?user=U19d3hYAAAAJ&hl=en&oi=ao | |
| Post-doc | |
| MRC
National Institute for Medical Research |
|
| Division of Molecular Structure | |
| London | |
| United Kingdom | |
| www.nimr.mrc.ac.uk/ | |
| Italy |
EMBO LTF
| 2010 | |
| King's College, London | |
| Randall Division of Cell and Molecular Biophysics | |
| London | |
| United Kingdom |
Research Interests
| Structural Biology and Biophysics | |
| I am a structural biologist with a strong background in biophysics. At the beginning of my career, I was interested in the higher order DNA structures and about the possibility of using them as a starting point to obtain potential aptamers (specific inhibitors of protein functions), especially in the context of telomerase. During my first postdoc, funded by EMBO, I became very interested in investigating the structure and function of proteins involved in RNA biology. In particular, I worked on the La protein and the La Related Proteins (LARPs) trying to understand the structural reason for their ability to recognise different RNA targets. | |
| Yang R, Gaidamakov SA, Xie J, Lee J, Martino L, Kozlov G, Crawford AK, Russo AN, Conte MR, Gehring K, Maraia RJ.
La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability. Mol Cell Biol. 2011 Feb;31(3):542-56. Epub 2010 Nov 22. |
|
| Martino L, Pennell S, Kelly G, Bui TT, Kotik-Kogan O, Smerdon SJ, Drake AF, Curry S, Conte MR. Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Nucleic Acids Res. 2011 Oct 18. [Epub ahead of print]- PMID: 22009680 | |
| Merret R, Martino L, Bousquet-Antonelli C, Fneich S, Descombin J, Billey E, Conte MR, Deragon JM. The association of a La module with the PABP-interacting motif PAM2 is a recurrent evolutionary process that led to the neofunctionalization of La-related proteins. RNA. 2013. 19(1):36-50. |
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