For living, cells need to transmit the whole content of their genetic information to their descendants. Chromosomes are the support of this genetic information. Cells replicate chromosomes in two identical copies called sisters chromatids. The segregation of these sister chromatids to each daughter cell has to be very accurate. Any mistake in segregation creates aneuploid cells which quickly dies or evolves to cancer. My research is focus on the understanding of chromosome segregation mechanisms.
Maure, J.F., E. Kitamura, and T.U. Tanaka, Mps1 Kinase Promotes Sister-Kinetochore Bi-orientation by a Tension-Dependent Mechanism. Curr Biol, 2007. 17(24): p. 2175-82.
Bernard P, Drogat J, Maure JF, Dheur S, Vaur S, Genier S, Javerzat JP. A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. Curr Biol. 2006 May 9;16(9):875-81.
Bernard P*, Maure JF*, Partridge JF, Genier S, Javerzat JP, Allshire RC. Requirement of heterochromatin for cohesion at centromeres. Science. 2001 Dec 21; 294(5551):2539-42. (* co-authors)
Bernard P, Maure JF, Javerzat JP. Fission yeast Bub1 is essential in setting up the meiotic pattern of chromosome segregation. Nat Cell Biol. 2001 May; 3(5):522-6.