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Alessandra Cambi

Contact Info

Alessandra Cambi
First Name:	Alessandra
Last Name:	Cambi
Personal webpage:	www.ncmls.nl/principal-investigators/cambi/
Current Position:	Assistant Professor
Institute:	Nijmegen Centre for Molecular Life Sciences
Department:	Tumor Immunology
City:	Nijmegen
Country:	Netherlands
Lab webpage:	www.ncmls.eu
Nationality:	Italy

EMBO LTF

Year LTF application:	2005
Institute of LTF:	Max Planck Institute for Biophysical Chemistry
Department of LTF:	Molecular Biology
City of LTF:	Goettingen
Country of LTF:	Germany

Research Interests

Research Area:	Immunology
Main research interests:	Research interests include immunology and cell biology, with a specific focus on the application of high resolution microscopy to unravel the organisation and dynamics of receptors and lipids at the plasma membrane. Major current projects include the investigation of the role of plasma membrane lipids in the regulation of pathogen receptor functions on dendritic cells as well as the function of prostaglandin receptors involved in the communication between dendritic cells and mast cells.
Publication 1:	Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion. van Zanten TS, Cambi A, Koopman M, Joosten B, Figdor CG, Garcia-Parajo MF. Proc Natl Acad Sci U S A. 2009 Oct 22. [Epub ahead of print] (*equally contributing) PMID: 19850864
Publication 2:	1. Koen van den Dries, Suzanne FG van Helden, Joost te Riet, Ruth Diez-Ahedo, Carlo Manzo, Machteld M Oud, Frank N van Leeuwen, Roland Brock, Maria F Garcia-Parajo, Alessandra Cambi and Carl G Figdor (2012) “Geometry sensing by dendritic cells dictates spatial organization and PGE2-induced dissolution of podosomes.” Cell Mol Life Sci 2011 Dec 28. [Epub ahead of print]
Publication 3:	Cambi A, Lidke DS, Arndt-Jovin DJ, Figdor CG, Jovin TM, Ligand-Conjugated Quantum Dots Monitor Antigen Uptake And Processing By Dendritic Cells, Nano Lett., 2007 IN PRESS
Publication 4:	Cambi A and Lidke DS (2012) “Nanoscale membrane organization: where biochemistry meets advanced microscopy.” ACS Chem Biol. 7(1):139-49.
Publication 5:	Tacken P, Ginter W, Berod L, Cruz LJ, Joosten B, Sparwasser T, Figdor GC and Cambi A (2011) “Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation and cross-presentation.” Blood. 118(15):4111-9.

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