Alexander Knight, National Physical Laboratory, Middlesex, UK
This is the first book which reviews what has been learnt about the mechanism of different biological systems from the application of biological techniques (rather than focussing on the techniques themselves).Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective. The contents are organized by biological system or molecule. Systems covered include molecular motors (kinesin, dynein, myosin and the bacterial flagellar motor); nucleic acids (Chromatin, DNA-based enzymes and the ribosome); membranes (including a chapter on ion channels) and a look at applications to microarray technology.
For more details see http://www.elsevier.com/inca/716675 .